In 1998 Pfizer's Viagra was approved by the FDA to treat erectile dysfunction. I was only 5 years old at the time and, of course, knew nothing about erectile dysfunction. I was happy I was allowed to start early my first grade. I did extremely well in elementary then high school. In fact, I was encouraged to go for examinations intended for higher classes and passed all of them in the 98th percentile. As a result, they let me skip 3 years and finish high school at 15. I was elated and joined Pfizer as a research assistant, working for free to gather some experience.
I joined the team that was working on a new anti inflammatory drug called Bextra. Initial results were encouraging and the company began selling it. However, several fatal skin infections occurred with it's use and the FDA recommended to cancel the program. Subsequently, I joined a team that was working on immunotherapy for cancer.
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At the age of 18, I was still part of that team and, by now, salaried for over a year. I liked the members of the team but saw a limited future in the direction they were going. More importantly, too many groups in other drug companies were working on similar projects. I stayed with them but was looking for a more challenging and less crowded subject to work on.
So, returning to Viagra. As I said, it was approved for men in 1998. There was great enthusiasm that it would work for women too, but the trial was unsuccessful, and Pfizer quit their efforts about 'Viagra for women' in 2004. A drug called Addyi to increase libido in women was manufactured later by another company. If you haven't heard about it, no wonder. Unlike Viagra for men, Addyi's effects were mild, if any, and the price was sky high. It never caught up.
I loved intelligence challenges and was intrigued by the subject. I was a virgin and never officially dated a girl before. As a young male with raging hormones, I tried my luck a couple of times, but my clumsy approach and lame opening lines led to one failure after the other. I was 6'0", 180 pounds, average looking guy, but I was seen as a brainiac more than a heartthrob, and to sum up my success with the other gender was one big 0.
To satisfy my curiosity about women libido enhancement drug, I've read thousands of articles about women's sexuality, libido, and orgasm, as well as manuscripts about Viagra, Cialis, and Addyi. My conclusion was that the major hurdle was related to the different triggers men and women required to reach a climax. Men are built much simpler than women - Visual and tactile stimuli were enough to cause arousal and erection in the vast majority of men, irrespective of other issues. In contrast, most women needed 'to be in the mood' even if everything else was perfect.
As one who has already been promoted twice at Pfizer, I had access to many substances that were used in our trials. I started with sildenafil citrate, which was the active ingredient in Viagra, and decided to continue along the path that Pfizer quit years earlier. I built a miniature lab in our basement and 'borrowed' certain ingredients I wished to try from my workplace. I wasn't sure what to expect and whether I was in the right direction but I had nothing to lose. As a declared nerd, I had no close friends (Noah and I chatted on occasions, but we never went together to movies, bars, or other social events, so he didn't count) and, as I mentioned before, no girlfriend.
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I found it funny that in my wet dreams, I never fantasized about Della, the prettiest cheerleader, or Kerry, the rich kid with the F+ cup tits. It was always about my mother.
While I haven't mentioned it, my father died of a rare autoimmune disease years ago, and Mom and I lived in the suburbs. In retrospect, she was the only female I ever saw in underwear. My mother was almost 50 years old, 5'4", 140-145 pounds, somewhat chubby, and had large breasts (Although not quite as prominent as Kerry's). As your average 18 year old, full-of-testosterone pervert male, I checked her underwear drawers and the laundry basket on a regular basis, and in addition to dreaming about her, I used her items to enhance my masturbatory experiences.
My mother was the only friend I could relate to. She worked part-time at a large grocery store and had enough time to care for me as a child. The combination of Dad's savings and his generous life insurance was enough to allow us to live comfortably, so my mother applied for the job to feel useful and fill the mornings when I was at school.
When I began working at Pfizer, I returned home at later hours. So Mom registered to a nearby health club and every afternoon attended the place for about 2 hours. When she asked for my opinion about her move, I said it was a fantastic idea. Mom blushed and said she used to love sports in high school. She got married at 18.5 and had me less than 2 years after that, so she had no time to spare for sports. Since her husband died, she hadn't been feeling the same joy of living, so she neglected herself, and gained a lot of weight.
I said, "Mom, in my book, you are the most beautiful woman in the world."
She laughed, "I know. And I love you too."
In the months that followed, my mother continued wearing her baggy clothes or loose robes at home. One day, I saw her moving from the bathroom to her bedroom and noticed that her tummy was much smaller. While her breasts did not change much, they looked bigger over her slimmer figure. At dinner, I complimented her on her weight loss and asked for her current weight.
She grinned, "Thank you. I felt like an ugly cow before and looked for excuses to avoid getting into shape. Call it depression after Dad's passing or laziness. But now I had nobody else to blame but me, so at 50 it was time to start over. Every day, I swim for half an hour, alternate treadmill with elliptical for 40 minutes, and the rest of the time spend in the jacuzzi or wet sauna with oldies like me, gossiping about everything and everybody. At the start, I weighed 145 pounds, and now, it is 135 pounds. I am proud of myself and hope in 2 months, on my official 50th birthday, to get under 130 pounds."
"Mom, you look great already. Will you marry me?"
We had a good laugh together, but since that time, my fantasies about Mom became more prevalent and... wilder.
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Most of my evenings were dedicated to work on my 'Viagra-for-women' project. I messed with the sildenafil molecule, tested different combinations, added certain atoms that, in theory, were not supposed to work and failed to get something meaningful.
All my test animals were rats. And except for one combination that made male rats more aggressive, whatever I tested on them did not show any effect on their behavior.
I was supposed to test the 10 new formulas I produced. I approached the rats cages and slipped on an Erlenmeyer I left on the floor the night before. One of the test tubes fell into a cage and broke. Luckily, nothing happened to me, but it was useless to try and inject the content of the other tubes since I could not rule out a contamination.
I marked the ingredients of the broken tube, cleaned the floor from the broken glasses as I heard a lot of commotion at the rats cages. I went to see what was going on and saw all the female rats in the vicinity of the broken tube area trying to solicit the males by initiating a present posture, and the males competed to get to them. WTF?
Was this the compound I was looking for? The following evening, I spilled 3 drops in a cage that was far away and waited. Exactly 2 minutes later, the 3 females presented themselves the same way, declaring they were interested. I was anxious to test it on bigger animals. I went to one of the kill shelters, where they euthanize dogs that did not get adopted within the grace period of 72 hours, and offered to take 10 dogs, 7 females, and 3 males, between the ages of 3 and 10 years old. The shelter was happy to accommodate my request. For them, everything was better than killing the dogs, so they didn't ask questions.
Unbeknownst to Mom, I rented a small cabin in the scantly populated area near the forest, 10 miles from our house. The cabin itself was less important, but I rented it because the large property was well-fenced to protect the dogs from wildlife in the forest, and the dogs could not leave.
I wanted to check if the compound was effective in dogs, too. In case it was successful, I had to know HOW it performed, what DOSE was effective, and for HOW LONG it worked.
On the first day, I put them in their original cages, used a pipette to squirt 5 drops of the solution in each dog's food, and sat on the porch to watch the reaction. The female dogs, and I mean ALL 7 female dogs, became anxious within less than 5 minutes. They showed more aggressive behavior, urinated differently, and some howled. The males watched them and tried unsuccessfully to dig their way toward the females.
I opened all cages, and observed the dog's behavior. All the females moved in the direction of the males, began urinating near them, and raised their tails. suggestively. The male dogs seemed confused: The females behaved classically as if they were in heat, yet their urine did not have the proper smell. I waited to see how long the females behaved that way. It lasted until the wee hours of the night. I fell asleep in my chair and woke up around 6 am. Two female dogs were still courting 2 male dogs. They stopped 2 hours later. So, the range of action I estimated was 8-16 hours.
I went to work and returned to the cabin at 5 pm. This time, I put only 3 drops. The result was similar. I was happy neither of the dogs showed obvious early side effects.
